{"product_id":"buy-hgh-191-177","title":"HGH 191-177","description":"\u003ch3\u003e\u003cspan class=\"\"\u003eProduct Specifications\u003c\/span\u003e\u003c\/h3\u003e\n\u003cdiv class=\"ds-scroll-area ds-scroll-area--show-on-focus-within ds-scroll-area--enabled _1210dd7 c03cafe9\"\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003e\u003cspan class=\"\"\u003eSpecification\u003c\/span\u003e\u003c\/th\u003e\n\u003cth\u003e\u003cspan class=\"\"\u003eDetail\u003c\/span\u003e\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eProduct Class \/ Category\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eGrowth Hormone Peptide Fragment\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eResearch Identifier\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eHGH Fragment 177‑191 (synonym HGH 191‑177), CAS 1262237‑79‑5\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eHPLC Purity Threshold\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003e\u0026gt;99% (routine batch-specific HPLC at 214 nm)\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eTarget Receptors \/ Chemical Pathways\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eGrowth Hormone Receptor (GHR) extracellular domain – selective in‑vitro interaction at site‑2 binding pocket; lipolytic signaling observed in 3T3‑L1 adipocyte research models\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eRegulatory Status\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan class=\"\"\u003eFor In‑Vitro \u0026amp; Laboratory Analytical Research Only. Not for human, veterinary, diagnostic, or therapeutic use.\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003chr\u003e\n\u003ch2\u003e\u003cspan class=\"\"\u003eResearch Overview \u0026amp; Mechanism of Action\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eHGH 191‑177 is a synthetic 15‑amino acid C‑terminal fragment of human somatotropin. The sequence spans residues 177 through 191 — hence the dual naming — and carries an intramolecular disulfide bridge between Cys‑182 and Cys‑189. Its monoisotopic mass weighs 1815.1 Da. The primary structure reads Leu‑Arg‑Ile‑Val‑Gln‑Cys‑Arg‑Ser‑Val‑Glu‑Gly‑Ser‑Cys‑Gly‑Phe.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThis fragment has zero growth‑promoting activity. That’s well documented. Instead, it binds the growth hormone receptor through the site‑2 contact surface without triggering the conformational dimerization required for full‑length signalling. In multiple in‑vitro adipocyte models, the peptide shifts the GHR into a partially activated state that uncouples lipolytic readouts from IGF‑1 transcription. Researchers therefore use HGH 191‑177 as a probe to dissect biased signalling downstream of the GHR. Receptor selectivity, molar ratio‑dependent binding curves, and long incubation‑time stability are the aspects that matter most in the lab.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eAnalytical control is built into every lot. We rely on reverse‑phase HPLC with a C18 column and electrospray ionisation mass spectrometry. The chromatogram routinely lands at \u0026gt;99% area under the curve. The lyophilized cake often looks cracked or slightly displaced. That’s normal. Rapid freeze‑drying and transport vibration cause the dried matrix to fracture without altering peptide integrity.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan class=\"\"\u003eHandling, Reconstitution \u0026amp; Storage Protocol\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eKeep the lyophilized vial at –20 °C for long‑term storage. Room‑temperature transit for a few days causes no measurable degradation. Let the sealed vial sit at ambient lab temperature for at least 15 minutes before you crack the cap. Condensation invites moisture‑driven aggregation — skip that step and you risk a cloudy reconstitution.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eReconstitution protocol for analytical concentration:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eUse sterile bacteriostatic water (0.9% benzyl alcohol) or phosphate‑buffered saline, pH 7.4.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eDraw the desired volume into a low‑dead‑volume syringe, then inject gently down the glass wall.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli class=\"ds-markdown-paragraph\"\u003e\n\u003cspan class=\"\"\u003eTarget a stock concentration of 1–2 mg\/mL. The peptide dissolves readily; gentle swirling is enough. Vortexing or foaming shears the peptide backbone.\u003c\/span\u003e\u003cspan class=\"\"\u003e\u003cbr\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eFor cell‑based assays where plastic‑ware adsorption is a concern, supplement the diluent with 0.1% molecular‑biology‑grade bovine serum albumin as a carrier protein. This step preserves free‑peptide molar ratio at sub‑micromolar working concentrations.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003ePost‑reconstitution shelf‑life: Store the solution at 2–8 °C and use within 2‑3 weeks for consistent in‑vitro results. Aliquot single‑use volumes and avoid freeze‑thaw cycling. A single freeze‑thaw cycle drops bioactive signal by roughly 15% in our internal stability trials — plan your aliquots accordingly.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003e\u003cspan class=\"\"\u003eScientific References \u0026amp; External Citations\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=HGH+177-191+fragment+lipolysis\" rel=\"noreferrer\" target=\"_blank\"\u003e\u003cspan class=\"\"\u003ePubMed: HGH Fragment 177‑191 Research\u003c\/span\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003e– Curated studies mapping the lipolytic domain of human growth hormone.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/substance\/?q=1262237-79-5\" rel=\"noreferrer\" target=\"_blank\"\u003e\u003cspan class=\"\"\u003ePubChem Compound: HGH Fragment 177‑191\u003c\/span\u003e\u003c\/a\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003e– Structural identifiers, molecular weight, and chemical classification.\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\n\u003ch2\u003e\u003cspan class=\"\"\u003eFrequently Asked Research Questions\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eWhat is the exact amino acid sequence and molecular weight of HGH 191‑177?\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan class=\"\"\u003eThe peptide corresponds to HGH residues 177‑191 with the sequence H‑Leu‑Arg‑Ile‑Val‑Gln‑Cys‑Arg‑Ser‑Val‑Glu‑Gly‑Ser‑Cys‑Gly‑Phe‑OH. The oxidised form, containing a Cys‑Cys intramolecular disulfide, has a monoisotopic mass of 1815.1 g\/mol. Both reduced and oxidised masses are confirmed on every batch CoA via ESI‑MS.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eHow should I reconstitute HGH 191‑177 for cell‑culture experiments?\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan class=\"\"\u003eAim for a stock analytical concentration of 1‑2 mg\/mL in sterile bacteriostatic water or PBS. Add 0.1% BSA to the final diluent if your protocol uses low‑micromolar working solutions on polystyrene plates. Swirl gently; mechanical agitation or prolonged vortexing degrades peptide integrity. Always allow the lyophilized cake to equilibrate to room temperature before adding the diluent.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eIs a batch‑specific Certificate of Analysis provided?\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan class=\"\"\u003eAbsolutely. Each 5 mg research vial leaves our laboratory with a printed and digitally archived CoA containing the HPLC purity reading, retention time, ESI‑MS spectrum, and observed peptide mass. The lot number printed on the vial matches the CoA one‑to‑one.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCan this \u003ca href=\"https:\/\/corepeptides.in\/\"\u003epeptide\u003c\/a\u003e be used in human diagnostics or therapeutic research?\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan class=\"\"\u003eNo. HGH 191‑177 is manufactured for in‑vitro analytical research only. It is not intended for human or veterinary administration, clinical diagnostics, or therapeutic use. All purchase orders are screened to ensure compliance with this research‑use‑only restriction.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Supplements","offers":[{"title":"Default Title","offer_id":54424659820757,"sku":null,"price":4999.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0817\/5796\/2453\/files\/ChatGPTImageAug4_2026_11_54_46PM.png?v=1785867925","url":"https:\/\/corepeptides.in\/products\/buy-hgh-191-177","provider":"Corepeptides India","version":"1.0","type":"link"}