IGF 1 LR3

IGF-1 LR3, also known as Long Arginine 3-Insulin-like Growth Factor-1 or LR3-IGF-1, is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1). This 83-amino-acid peptide is engineered through specific modifications to the amino acid sequence of mature human IGF-1, including the substitution of arginine for glutamic acid at position three and the addition of a 13-amino-acid N-terminal extension. With a molecular formula of C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉ and a molecular weight of approximately 9.1–9.2 kDa, IGF-1 LR3 is a recombinant protein belonging to the insulin gene family of mitogenic polypeptide growth factors.

IGF-1 LR3 is a potent activator of the IGF-1 receptor (IGF1R), functioning as a ligand that binds to the alpha subunit of the receptor, initiating the activation of intrinsic tyrosine kinase activity and autophosphorylation of tyrosine residues in the beta subunit. This activation triggers downstream signaling cascades, including the PI3K/AKT pathway and ERK1/2 signaling, which are responsible for promoting cell survival, proliferation, and differentiation. What distinguishes IGF-1 LR3 from native IGF-1 is its significantly reduced affinity—over 100-fold—for IGF-binding proteins (IGFBPs). This reduction in binding affinity results in substantially enhanced biological stability, a markedly prolonged half-life, and increased bioavailability in vitro. IGFBP-3 does not inhibit its activity, allowing for more sustained receptor engagement in cell culture models.

Researchers are particularly interested in IGF-1 LR3 due to its potent mitogenic and anabolic properties. It stimulates the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue. Studies have demonstrated that IGF-1 LR3 significantly increases myoblast proliferation and the formation of myotubes. It is also used in research related to tissue repair, development, and stem cell studies. Clinical research on IGF-1 LR3 has explored its potential in areas such as Alzheimer's disease, where it has been shown to promote amyloid plaque remodeling, and in fetal growth research.

At CorePeptides India, we are committed to providing premium-quality research peptides to the scientific community across India. Our IGF-1 LR3 peptide is manufactured under stringent quality control protocols and is intended exclusively for laboratory and in-vitro research applications. Whether you are conducting cell proliferation studies, signal transduction research, or exploring regenerative pathways, CorePeptides India offers a reliable source for your IGF-1 LR3 research needs.

Key Features

• Premium Quality – Each batch of IGF-1 LR3 peptide undergoes rigorous quality testing, including HPLC verification and mass spectrometry, to ensure high purity (≥95–98%) and consistency for reliable research outcomes.
• Research Use Only – Our IGF-1 LR3 is supplied strictly for laboratory and in-vitro research purposes, in compliance with applicable regulations.
• Secure Packaging – Peptides are packaged in high-quality vials with tamper-evident seals to maintain product integrity during storage and transit.
• Transparent Product Information – Detailed specifications, including purity levels, molecular characteristics, and sequence confirmation, are provided with every product.
• Fast Delivery Across India – We offer reliable shipping to research institutions, laboratories, and academic facilities across all major cities in India.
• Professional Customer Support – Our knowledgeable team is available to assist researchers with product inquiries and ordering assistance.

Product Specifications